Pancreatic Enzyme Products
INGREDIENTS: Digestive enzymes such as lipase, protease, and amylase
OTHER NAMES: Enzyme Therapy, Fungal Pancreatin, Pancreatic Enzyme Formulation, Pancreatic Enzyme Replacement Therapy (PERT), Pancreatic Enzymes, Pancreatin, Pancreatina, Pancréatine, Pancréatine Fongique, Pancreatinum, Pancreatis Pulvis, Pancrelipase, Thérapie Enzymatique
- Overview
- Usage
- Safety
- Interactions
- Dosing
- Others
| Usage | Effectiveness |
|---|---|
|
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| Proven | Safety |
USAGE AND EFFECTIVENESS
| Usage | Effectiveness |
|---|---|
| Nonalcoholic Fatty Liver Disease |
Mild effectiveness (Reduce liver fat content) Several clinical studies showing reduction in liver fat content, liver function and diarrhoea; clinical studies are not robust enough (one study is underpowered); more evidence is needed to support the above. Nonalcoholic Fatty Liver Disease is a condition where excess fats are accumulated in the liver of individuals who drink little to no alcohol, causing inflammation and liver damage. |
| Eczema |
Unclear effectiveness (Reduce severity of eczema) One clinical study to support the above point; but clinical study is not robust enough (limited by the lack of a comparator group); More evidence needed |
| HIV/AIDS |
Unclear effectiveness (Improve malabsorption which is common HIV/AIDS) One clinical study to support the above point; while there was improvement, large proportion of patients did not see full elimination of oily diarrhoea; more evidence needed |
| Pancreatic Cancer |
Unclear effectiveness (Reduce symptoms of digestive pancreatic cancer) Several clinical studies showing conflicting results (One showed increase in body weight while two other showed ineffectiveness in increasing body weight, quality of life, and survival); More evidence needed |
| Pancreatic Insuffiency |
Unclear effectiveness (Improve pancreas function) Several clinical studies showing conflicting results (Several studies show improvement in fat, protein and total energy absorption while two studies show no improvement in recovery time, body weight and protein level (serum albumin)); but clinical studies are not robust enough; more evidence is needed |
General Safety
- Generally safe when used orally and appropriately; Generally unsafe when used in high doses
Pregnant/Breastfeeding
- Little data to show it is safe or otherwise; avoid if possible
Children
- Generally safe when used orally and appropriately; Generally unsafe when used in high doses
Elderly
- Little data to show it is safe or otherwise; avoid if possible
Special to Note
- Unknown
Contraindications
- May affect blood sugar levels in individuals with diabetes
Side Effects
-
Generally safe; side effects may include:
Skin:May cause allergy reactions like rashes
Hormone System:May cause high or low blood sugar level
Digestive System: May cause nausea, vomiting, diarrhoea, bloatedness, dry mouth, constipation, stomach pain, and others
Brain/CNS: May cause headache and dizziness
Kidney: May cause high uric level but this is restricted to situation where high dose of Pancreatic Enzyme is used
- Medicines
Medium severity interactions with medicines for diabetes (interfere with the effectiveness of starch blocker) - Supplements
Medium severity interactions with herbs and supplements that contain folic acid - decrease absorption - Food
Interacts with acidic (e.g. fruit juices) and alkaline (e.g. chicken, veal, or green beans) food; make Pancreatic Enzyme Products less effective - Lab Tests
Interactions with lab test for uric acid
- Nonalcoholic fatty liver disease (Adults)
1800mg daily for 6-12 months (Prescription dosage); 1800mg or 3 grams daily for 10-12 months (Non-Prescription dosage). It should be noted that taking supplements during cancer therapy and cancer-free phase present a risk to health and the attending doctor should be consulted prior to taking any supplements. - Pancreatic Cancer (Adults)
50,000 lipase units per meal, thrice daily for up to 8 weeks - Pancreatic Insufficiency (Adults)
500-1000 lipase units/kg per meal (Starting Dose); Maximum 2500 lipase units/kg per meal, or 4000 lipase units/gram fat per day - Eczema (Children)
Below 7 years old, 37,500 units protease per meal and 18,750 units per snack; 7 years old and older, 75,000 units protease per meal, 37,500 units per snack - HIV/AIDS (Children)
1000 units/gram of fat for up to 2 weeks - Pancreatic Insufficiency (Children)
500-1000 lipase units/kg per meal (Starting Dose); Maximum 2500 lipase units/kg per meal, or 4000 lipase units/gram fat per day
- General Information
- Pancreatic enzyme products are used by consumers for pancreatic cancer, HIV/AIDS, eczema, diabetes, digestion, and others
- How does it work?
- Contain digestive enzymes that break down starch, protein and fats
| Effectiveness Score | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Gold Standard | You should always consider taking this supplement. Do check if your health professional has any objection to you taking this supplement. |
| 4 | Effective | This supplement may be helpful. You may consider taking this. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 3 | Mildly Effective | This supplement may be mildly helpful. You may consider taking this if the benefit outweighs the risk. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 2 | Unclear Effectiveness due to Conflicting Results or Limited Benefit | This supplement may not provide a clear benefit to the issue(s) you seek to resolve. Do consult your health professional if you still decide to go ahead to take this. |
| Effectiveness Score | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Gold Standard | You should always consider taking this supplement. Do check if your health professional has any objection to you taking this supplement. |
| 4 | Effective | This supplement may be helpful. You may consider taking this. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 3 | Mildly Effective | This supplement may be mildly helpful. You may consider taking this if the benefit outweighs the risk. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 2 | Unclear Effectiveness due to Conflicting Results or Limited Benefit | This supplement may not provide a clear benefit to the issue(s) you seek to resolve. Do consult your health professional if you still decide to go ahead to take this. |
| 1 | Unknown Effectiveness | There is no evidence of benefit for taking this supplement. Do consult your health professional if you still decide to go ahead to take this. |
| 0 | Proven to be Not Effective | Taking this supplement has been proven to be ineffective. Do consult your health professional if you still decide to go ahead to take this. |
| Amount of Medical Evidence | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Proven by One or More Well Designed Analysis of Several Well Designed Medical Studies | You can rest assured that this supplement can do what it claims to do. |
| 4 | Proven by several well designed medical studies | You have good confidence that this supplement will do what it claims to do. |
| 3 | Proven by One Well Designed Medical Study | You have some confidence that this supplement will do what it claims to do. |
| 2 | Proven by One or Several Not Well Designed Medical Studies | There may be doubts about whether this supplement can do what it claims. Consider if this is necessary. |
| 1 | No Study Done or Proven by Weakly Designed Medical Studies | There are many doubts about whether this supplement can do what it claims. Consider if this is necessary. |
| 0 | Proven to be Ineffective or Harmful | You should strongly consider not to use this unless advised by your health professionals. |
| Safety Score | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Safe for Everyone | This supplement is most likely to be safe for you. You may consider taking this. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 4 | Safe for General Population, with Unknown Effect on Special Population | This supplement is likely to be safe for you, except for certain circumstances. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 3 | ||
| 2 | Safe for General Population but may be Unsafe for Certain Population or have Certain Rare Side Effect | This supplement may be safe for you if you do not have any medical conditions or concurrent medication. Do consult your health professional before taking it. |
| 1 | Unknown Safety | Unless you are very healthy and have no concurrent medical conditions and medication, you should not take it. Even if safety is not an issue, you should only consider taking it if the benefit is deemed to be more than the risk. Please consult your health professional should you decide to take the supplement. |
| 0 | Unsafe | You must not take this. Please consult your health professional should you decide otherwise. |
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