Papain
INGREDIENTS: Cysteine proteinases such as chymopapain A, chymopapain B, papaya peptidase A, caricain, bromelain, actinidin, ficin, aleurain, and lysosomal cathepsins B, H, L, S, C, and K.
OTHER NAMES: Concentré de Protéase Végétale, Papaina, Papaïne, Papainum Crudum, Pepsine Végétale, Plant Protease Concentrate, Protease, Protéase, Vegetable Pepsin
- Overview
- Usage
- Safety
- Interactions
- Dosing
- Others
| Usage | Effectiveness |
|---|---|
|
|
| Proven | Safety |
USAGE AND EFFECTIVENESS
| Usage | Effectiveness |
|---|---|
| Shingles |
Unclear effectiveness (Improve symptoms of shingles) One clinical study to support the above point; but clinical study is not robust enough; More evidence needed |
| Sore Throat |
Unclear effectiveness (Reduce throat inflammation and swelling) One clinical study to support the above point; but clinical study is not robust enough; More evidence needed |
| Exercise-induced Muscle Ache & Soreness |
Unclear effectiveness (Improve muscle aches and soreness due to exercise) One clinical study to support the above point; but clinical study is not robust enough; more evidence needed |
| Jellyfish Stings |
Unclear effectiveness (Improve wound healing of jellyfish stings) One clinical study to support the above point; but clinical study is not robust enough; more evidence needed |
| Radiation Sickness |
Unclear effectiveness (Improve radiation sickness) Two clinical studies showing conflicting results (One shows taking it reduces genitourinary (genital and urinary organs) symptoms and skin reactions while another shows taking it does not reduce radiation-related complications (nausea, vomiting, fatigue and skin reactions; more evidence is needed |
| Wounds |
Unclear effectiveness (Improve wound healing) One clinical study to support the above point; but clinical study is not robust enough; more evidence needed |
| Insect Bites |
Unknown effectiveness (Does not reduce pain and itching) No clinical study to support the above point; More evidence needed |
General Safety
- Generally safe when used orally and appropriately; Generally unsafe when consumed orally in large amount
Pregnant/Breastfeeding
- Generally unsafe when used during pregnancy; Unknown safety when used during breast-feeding
Children
- Little data to show it is safe or otherwise; avoid if possible
Elderly
- Little data to show it is safe or otherwise; avoid if possible
Special to Note
- Individuals are advised to not take the supplement 2 weeks before the operation. Avoid consuming in large amount.
Contraindications
-
May cause allergy reactions in individuals with papain,fig or kiwi allergy
May increase bleeding in individuals with bleeding conditions
Side Effects
-
Generally safe; side effects may include:
Skin:May cause itching
Digestive system:May cause diarrhoea, gastric ulcer, esophageal perforation ), and gastritis
Genital/Urinary:May cause high sodium level in the blood
Blood:May develop symptoms of warfarin overdose
Respiratory System: May cause respiratory allergy reactions
- Medicines
Potential interactions with medicines for blood clotting - Supplements
Potential interactions with herbs and supplements that contain papaya/ papain - Food
Potential interactions with food such as fig, kiwi, and potato protein - Lab Tests
None known
- Shingles (Adults)
Consume up to 14 days - Sore throat
Consume 2mg daily (in combination with other ingredients) for up to 4 days
- General Information
- Papain is used by consumers to reduce inflammation and swelling after trauma and surgery, help with digestion, sore throat, muscle soreness, shingles, chronic diarrhoea and others
- How does it work?
- Contains chemicals that reduce healing time, increase immune system stimulation, and improve the skin condition
| Effectiveness Score | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Gold Standard | You should always consider taking this supplement. Do check if your health professional has any objection to you taking this supplement. |
| 4 | Effective | This supplement may be helpful. You may consider taking this. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 3 | Mildly Effective | This supplement may be mildly helpful. You may consider taking this if the benefit outweighs the risk. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 2 | Unclear Effectiveness due to Conflicting Results or Limited Benefit | This supplement may not provide a clear benefit to the issue(s) you seek to resolve. Do consult your health professional if you still decide to go ahead to take this. |
| Effectiveness Score | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Gold Standard | You should always consider taking this supplement. Do check if your health professional has any objection to you taking this supplement. |
| 4 | Effective | This supplement may be helpful. You may consider taking this. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 3 | Mildly Effective | This supplement may be mildly helpful. You may consider taking this if the benefit outweighs the risk. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 2 | Unclear Effectiveness due to Conflicting Results or Limited Benefit | This supplement may not provide a clear benefit to the issue(s) you seek to resolve. Do consult your health professional if you still decide to go ahead to take this. |
| 1 | Unknown Effectiveness | There is no evidence of benefit for taking this supplement. Do consult your health professional if you still decide to go ahead to take this. |
| 0 | Proven to be Not Effective | Taking this supplement has been proven to be ineffective. Do consult your health professional if you still decide to go ahead to take this. |
| Amount of Medical Evidence | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Proven by One or More Well Designed Analysis of Several Well Designed Medical Studies | You can rest assured that this supplement can do what it claims to do. |
| 4 | Proven by several well designed medical studies | You have good confidence that this supplement will do what it claims to do. |
| 3 | Proven by One Well Designed Medical Study | You have some confidence that this supplement will do what it claims to do. |
| 2 | Proven by One or Several Not Well Designed Medical Studies | There may be doubts about whether this supplement can do what it claims. Consider if this is necessary. |
| 1 | No Study Done or Proven by Weakly Designed Medical Studies | There are many doubts about whether this supplement can do what it claims. Consider if this is necessary. |
| 0 | Proven to be Ineffective or Harmful | You should strongly consider not to use this unless advised by your health professionals. |
| Safety Score | What does it mean | Action to be taken by you |
|---|---|---|
| 5 | Safe for Everyone | This supplement is most likely to be safe for you. You may consider taking this. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 4 | Safe for General Population, with Unknown Effect on Special Population | This supplement is likely to be safe for you, except for certain circumstances. Do consult your health professional if you have any medical condition or if you are taking any medication. |
| 3 | ||
| 2 | Safe for General Population but may be Unsafe for Certain Population or have Certain Rare Side Effect | This supplement may be safe for you if you do not have any medical conditions or concurrent medication. Do consult your health professional before taking it. |
| 1 | Unknown Safety | Unless you are very healthy and have no concurrent medical conditions and medication, you should not take it. Even if safety is not an issue, you should only consider taking it if the benefit is deemed to be more than the risk. Please consult your health professional should you decide to take the supplement. |
| 0 | Unsafe | You must not take this. Please consult your health professional should you decide otherwise. |
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